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2022;27:e13211

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Taken together, it has been proposed that muscle loss during GLP-1 RAs-based therapy is largely adaptive and proportional to overall weight reduction, and that improvements in muscle quality and insulin sensitivity may help offset potential functional decline [97]

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Lower affinity for IGF binding proteins means more free, bioactive IGF-1 LR3 in circulationmaximizing receptor engagement and anabolic effects

Positive-negative KG cassettes for construction of multi-gene deletions using a single drug marker